This is a known compatibility issue between SystmOne and Windows 10 / Microsoft Office.
If you are having problems opening/saving Microsoft Word documents on SystmOne, please try the solution below.
Open a blank Microsoft Word document > click 'File' top left of screen.
Select 'Options' from the blue left hand menu.
Select 'Trust Center' at bottom of menu > click 'Trust Center Settings...'.
Select 'Trusted Locations' from menu > click 'Add new location'.
Paste C:\apps\tpp\temp into the highlighted box shown below.